Sequence requirements for RNA strand transfer during nidovirus discontinuous subgenomic RNA synthesis
نویسندگان
چکیده
منابع مشابه
Synthesis of subgenomic RNAs by positive-strand RNA viruses.
f b w t ( t g s p t n p Many RNA viruses encode more than one gene on a single genomic RNA. Yet only the first gene, or open reading frame (ORF), on a normal eukaryotic mRNA is translated. Thus, downstream genes on viral genomes are expressed either via novel translational events or, more commonly, by deployment of subgenomic mRNAs (sgRNAs). Subgenomic RNAs of positive-strand viruses have the s...
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Coronavirus transcription leads to the synthesis of a nested set of mRNAs with a leader sequence derived from the 5' end of the genome. The mRNAs are produced by a discontinuous transcription in which the leader is linked to the mRNA coding sequences. This process is regulated by transcription-regulating sequences (TRSs) preceding each mRNA, including a highly conserved core sequence (CS) with ...
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Many positive-stranded RNA viruses use subgenomic mRNAs to express part of their genetic information. To produce structural and accessory proteins, members of the order Nidovirales (corona-, toro-, arteri- and roniviruses) generate a 3' co-terminal nested set of at least three and often seven to nine mRNAs. Coronavirus and arterivirus subgenomic transcripts are not only 3' co-terminal but also ...
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Nidoviruses produce an extensive 3'-coterminal nested set of subgenomic (sg) mRNAs, which are used to express structural proteins and sometimes accessory proteins. In arteriviruses and coronaviruses, these mRNAs contain a common 5' leader sequence, derived from the genomic 5' end. The joining of the leader sequence to different segments derived from the 3'-proximal part of the genome (mRNA bodi...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2001
ISSN: 1460-2075
DOI: 10.1093/emboj/20.24.7220